The Science of Stress and How Meditation Helps
By Dr. Punam Rana MD MSc • Physician & Meditation Teacher

Understanding the Stress Response
The stress response—often called the “fight-or-flight” response—is an ancient biological mechanism designed to help us survive immediate danger. When we perceive a threat, the brain signals the sympathetic nervous system to release hormones like adrenaline and cortisol. These prepare us for quick, decisive action.
While this response is adaptive in the short term, chronic stress has profound negative effects on our health. Let’s look at how stress impacts the body—and how meditation can help reverse these effects.
Short-Term vs. Chronic Stress: The Body’s Response
1. Physical Performance
Adrenaline boosts heart rate, blood pressure, and muscle oxygenation for fast reaction. Cortisol increases blood sugar to provide immediate energy. In the short term, this enhances physical performance.
Over time, however, chronic stress can lead to high blood pressure, insulin resistance, cardiovascular strain, and an increased risk of type 2 diabetes.
2. Immune Function
Initially, stress hormones can stimulate immune responses. But prolonged cortisol exposure suppresses immunity, increasing susceptibility to infections, autoimmune conditions, and slower recovery from illness.
3. Mood and Mental Health
Stress can initially cause alertness or even euphoria. But chronic stress disrupts neurotransmitters, increasing the risk of depression, anxiety, irritability, and emotional exhaustion.
4. Cognitive Function
In small doses, cortisol can improve memory and decision-making. But chronic stress impairs focus, memory, and cognitive flexibility—contributing to burnout and brain fog.
5. Pain Perception
In the short term, the body releases endorphins to blunt pain. Chronic stress, however, sensitizes the nervous system, making us more vulnerable to headaches, migraines, and chronic pain conditions.
How Meditation Reduces Stress
Meditation activates the parasympathetic nervous system—also known as the “rest-and-digest” response. It lowers stress hormone levels and restores balance to the body’s systems.
Studies have also shown that consistent meditation practice is associated with reduced right amygdala volume—the brain’s fear and stress center. Over time, this can lead to a calmer baseline emotional state.
✨ Physiological Benefits of Meditation Include:
- Decreased heart rate
- Lower blood pressure
- Improved heart rate variability
- Relaxed muscles and reduced tension
- Improved immune function
- Better sleep quality
- Lower inflammation markers
- Enhanced digestion
- Increased bladder activity regulation
Getting Started with Meditation
As a physician and meditation teacher, I encourage everyone to explore meditation as a powerful stress-reduction tool. Even a few minutes a day can help regulate your nervous system and bring more clarity and calm into your life.
To learn more about how to start meditating, explore my post: A Beginner’s Guide to Meditation and Well-being.
If you’re dealing with chronic stress or related health conditions, reach out to a healthcare provider. A comprehensive, personalized plan can support both your mental and physical health.
